Kynurenine hydroxylase: a potential rate-limiting enzyme in tryptophan metabolism.

نویسندگان

  • D A Bender
  • G M McCreanor
چکیده

Phillips, R. S. & Kaufman, S. (1984) J. Biol. Chem. 259,2474-2479 Pogson, C. I., Carpenter, W. R., Cook, J . S., Fisher, M. J., Lomax, M. A,, Salter, M. &Stanley, J . C. (1984) Proc. Nutr. Soc. 43, 119132 Salter, M., Stanley, J. C., Fisher, M. J. & Pogson, C. I. (1984) Biochem. J . 221, 431-438 Shiman, R. & Jefferson, L. S. (1982) J. Biol. Cham. 257, 839-844 Shiman, R., Mortimore, G. E., Schworer, C. M. & Gray, D. W.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The role of the kynurenine pathway of tryptophan metabolism in cardiovascular disease

Coronary heart disease and stroke, the deadliest forms of cardiovascular disease (CVD), are mainly caused by atherosclerosis, a chronic inflammatory disease of the artery wall driven by maladaptive immune responses in the vessel wall. Various risk factors for CVD influence this pathogenic process, including diabetes mellitus, hypertension, dyslipidaemia, and obesity. Indoleamine 2,3-dioxygenase...

متن کامل

Preclinical assessment of a novel small molecule inhibitor of tryptophan 2,3-dioxygenase 2 (TDO2)

Introduction iTeos leverages the science of LICR to target metabolism of the tumor microenvironment and develops small molecule immunomodulators. TDO2 is a heme-containing enzyme highly expressed in the liver, in specific brain regions and liver/brain tumors. It catalyses the first and rate-limiting step of tryptophan catabolism along the kynurenine pathway and thereby regulates systemic trypto...

متن کامل

Peripheral distribution of kynurenine metabolites and activity of kynurenine pathway enzymes in renal failure.

We investigated L-kynurenine distribution and metabolism in rats with experimental chronic renal failure of various severity, induced by unilateral nephrectomy and partial removal of contralateral kidney cortex. In animals with renal insufficiency the plasma concentration and the content of L-tryptophan in homogenates of kidney, liver, lung, intestine and spleen were significantly decreased. Th...

متن کامل

Kynuremine Metabolism in Hyperthyroidism A RIOCHEMICATA BASIS FOR THE LOW NAD(P) LEVEL IN HYPERTHYROID RAT LIVER*

Subcutaneous administration of L-thyroxine (75 pg/lOO g of body weight per day) to rats for 10 to 14 days caused a decrease in the activity of kynurenine 3-hydroxylase to about 50% of the control value. Enzymic properties of kynurenine 3-hydroxylase of mitochondrial outer membrane preparations isolated from normal and L-thyroxine-treated rats were almost identical, suggesting that L-thyroxine a...

متن کامل

Kynurenine metabolism in hyperthyroidism. A biochemical basis for the low NAD(P) level in hyperthyroid rat liver.

Subcutaneous administration of L-thyroxine (75 pg/lOO g of body weight per day) to rats for 10 to 14 days caused a decrease in the activity of kynurenine 3-hydroxylase to about 50% of the control value. Enzymic properties of kynurenine 3-hydroxylase of mitochondrial outer membrane preparations isolated from normal and L-thyroxine-treated rats were almost identical, suggesting that L-thyroxine a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Biochemical Society transactions

دوره 13 2  شماره 

صفحات  -

تاریخ انتشار 1985